Pandemic influenza vaccines.
Identifieur interne : 001060 ( Main/Exploration ); précédent : 001059; suivant : 001061Pandemic influenza vaccines.
Auteurs : Lauren J. Dimenna [États-Unis] ; Hildegund C J. ErtlSource :
- Current topics in microbiology and immunology [ 0070-217X ] ; 2009.
Descripteurs français
- KwdFr :
- Animaux, Attitude, Facteurs de risque, Flambées de maladies (), Grippe humaine (), Grippe humaine (immunologie), Grippe humaine (étiologie), Humains, Immunité innée, Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A, Vaccins antigrippaux (immunologie).
- MESH :
- immunologie : Grippe humaine, Vaccins antigrippaux.
- étiologie : Grippe humaine.
- Animaux, Attitude, Facteurs de risque, Flambées de maladies, Grippe humaine, Humains, Immunité innée, Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A.
English descriptors
- KwdEn :
- Animals, Attitude, Disease Outbreaks (prevention & control), Humans, Immunity, Innate, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H5N1 Subtype, Influenza Vaccines (immunology), Influenza, Human (etiology), Influenza, Human (immunology), Influenza, Human (prevention & control), Risk Factors.
- MESH :
- chemical , immunology : Influenza Vaccines.
- etiology : Influenza, Human.
- immunology : Influenza, Human.
- prevention & control : Disease Outbreaks, Influenza, Human.
- Animals, Attitude, Humans, Immunity, Innate, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H5N1 Subtype, Risk Factors.
Abstract
Since their compositions remain uncertain, universal pandemic vaccines are yet to be created. They would aim to protect globally against pandemic influenza viruses that have not yet evolved. Thus they differ from seasonal vaccines to influenza virus, which are updated annually in spring to incorporate the latest circulating viruses, and are then produced and delivered before the peak influenza season starts in late fall and winter. The efficacy of seasonal vaccines is linked to their ability to induce virus-neutralizing antibodies, which provide subtype-specific protection against influenza A viruses. If pandemic vaccines were designed to resemble current vaccines in terms of composition and mode of action, they would have to be developed, tested, and mass-produced after the onset of a pandemic, once the causative virus had been identified. The logistic problems of generating a pandemic vaccine from scratch, conducting preclinical testing, and producing billions of doses within a few months for global distribution are enormous and may well be insurmountable. Alternatively, the scientific community could step up efforts to generate a universal vaccine against influenza A viruses that provides broadly cross-reactive protection through the induction of antibodies or T cells to conserved regions of the virus.
DOI: 10.1007/978-3-540-92165-3_15
PubMed: 19768412
Affiliations:
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Le document en format XML
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Ertl</name></author></analytic><series><title level="j">Current topics in microbiology and immunology</title><idno type="ISSN">0070-217X</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Attitude</term><term>Disease Outbreaks (prevention & control)</term><term>Humans</term><term>Immunity, Innate</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza A Virus, H5N1 Subtype</term><term>Influenza Vaccines (immunology)</term><term>Influenza, Human (etiology)</term><term>Influenza, Human (immunology)</term><term>Influenza, Human (prevention & control)</term><term>Risk Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Attitude</term><term>Facteurs de risque</term><term>Flambées de maladies ()</term><term>Grippe humaine ()</term><term>Grippe humaine (immunologie)</term><term>Grippe humaine (étiologie)</term><term>Humains</term><term>Immunité innée</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Sous-type H5N1 du virus de la grippe A</term><term>Vaccins antigrippaux (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Grippe humaine</term><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Disease Outbreaks</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Attitude</term><term>Humans</term><term>Immunity, Innate</term><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza A Virus, H5N1 Subtype</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Attitude</term><term>Facteurs de risque</term><term>Flambées de maladies</term><term>Grippe humaine</term><term>Humains</term><term>Immunité innée</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Sous-type H5N1 du virus de la grippe A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Since their compositions remain uncertain, universal pandemic vaccines are yet to be created. They would aim to protect globally against pandemic influenza viruses that have not yet evolved. Thus they differ from seasonal vaccines to influenza virus, which are updated annually in spring to incorporate the latest circulating viruses, and are then produced and delivered before the peak influenza season starts in late fall and winter. The efficacy of seasonal vaccines is linked to their ability to induce virus-neutralizing antibodies, which provide subtype-specific protection against influenza A viruses. If pandemic vaccines were designed to resemble current vaccines in terms of composition and mode of action, they would have to be developed, tested, and mass-produced after the onset of a pandemic, once the causative virus had been identified. The logistic problems of generating a pandemic vaccine from scratch, conducting preclinical testing, and producing billions of doses within a few months for global distribution are enormous and may well be insurmountable. Alternatively, the scientific community could step up efforts to generate a universal vaccine against influenza A viruses that provides broadly cross-reactive protection through the induction of antibodies or T cells to conserved regions of the virus.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Ertl, Hildegund C J" sort="Ertl, Hildegund C J" uniqKey="Ertl H" first="Hildegund C J" last="Ertl">Hildegund C J. Ertl</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Dimenna, Lauren J" sort="Dimenna, Lauren J" uniqKey="Dimenna L" first="Lauren J" last="Dimenna">Lauren J. Dimenna</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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